Search results for "CC chemokine receptors"

showing 8 items of 8 documents

CC chemokine receptor 5 polymorphism in Italian patients with Beḩet's disease

2012

OBJECTIVE: To evaluate the potential role of CC chemokine receptor 5 (CCR5)Δ32 polymorphism in the susceptibility to and clinical expression of Behcet's disease (BD) in a cohort of Italian patients. METHODS: One hundred and ninety-six consecutive Italian patients satisfying the ISG criteria for BD were followed up for 8 years, and 180 healthy age- and sex-matched blood donors were molecularly genotyped for the CCR5Δ32 polymorphism. A standard microlymphocytotoxicity technique was used to serotype HLA-B51. The patients were subgrouped on the basis of the presence or absence of clinical manifestations. RESULTS: The distribution of the CCR5Δ32 genotype differed between BD patients and controls…

AdultMalemedicine.medical_specialtyHeterozygoteReceptors CCR5Behcet's disease CCR5 polymorphismBehcet's diseaseGastroenterologyRheumatologyGeneticGene FrequencyInternal medicineGenotypeReceptorsMedicineHumansPharmacology (medical)Genetic Predisposition to DiseaseAllelePolymorphismAllele frequencyPolymorphism Geneticbusiness.industryBehcet SyndromeHomozygoteCase-control studyOdds ratiomedicine.diseaseBeḩet's disease; CC chemokine receptor 5 Δ32 olymorphism; Chemokines; Disease manifestations; Adult; Behcet Syndrome; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-B Antigens; Heterozygote; Homozygote; Humans; Italy; Male; Polymorphism Genetic; Receptors CCR5; Rheumatology; Pharmacology (medical)Adult; Behcet Syndrome; Case-Control Studies; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-B Antigens; Heterozygote; Homozygote; Humans; Italy; Male; Polymorphism Genetic; Receptors CCR5ItalyHLA-B AntigensCase-Control StudiesImmunologyCohortFemalebusinessCC chemokine receptorsCCR5
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Natural Proteolytic Processing of Hemofiltrate Cc Chemokine 1 Generates a Potent Cc Chemokine Receptor (Ccr)1 and Ccr5 Agonist with Anti-HIV Properti…

2000

Hemofiltrate CC chemokine (HCC)-1 is a recently described human chemokine that is constitutively expressed in numerous tissues and is present at high concentrations in normal plasma. Using a cell line expressing CC chemokine receptor (CCR)5 as a bioassay, we isolated from human hemofiltrate an HCC-1 variant lacking the first eight amino acids. HCC-1[9–74] was a potent agonist of CCR1, CCR3, and CCR5 and promoted calcium flux and chemotaxis of T lymphoblasts, monocytes, and eosinophils. It also blocked entry of HIV-1 strains using CCR5 as coreceptor. Limited tryptic digestion of HCC-1 generated the active variant. Conditioned media from several tumor cell lines activated HCC-1 with a high ef…

AdultReceptors CCR5Anti-HIV AgentsReceptors CCR3Molecular Sequence DataImmunologyReceptors CCR1C-C chemokine receptor type 6BiologyChemokine receptorEndopeptidasesHumansImmunology and AllergyCCL17Amino Acid SequenceCalcium SignalingCCL15CCL13endopeptidaseChemotactic FactorsHIVBlood ProteinsMolecular biologyPeptide FragmentsChemotaxis LeukocyteBiochemistryChemokines CCCulture Media ConditionedXCL2Biological AssayReceptors ChemokineOriginal ArticleCC chemokine receptorsProtein Processing Post-TranslationalCCL21Journal of Experimental Medicine
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CCR5 Receptor: Biologic and Genetic Implications in Age-Related Diseases

2007

The CC chemokine receptor 5 (CCR5) is a member of CC-chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein-coupled receptor (GPCR), which regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age…

AgingChemokineReceptors CCR5Chemokine receptor CCR5virusesT cellViral pathogenesisDiseaseLigandsModels BiologicalGeneral Biochemistry Genetics and Molecular BiologyHistory and Philosophy of Sciencecardiovascular diseaseAlzheimer DiseasemedicineHumansMacrophageSettore MED/04 - Patologia GeneraleInflammationGenomebiologyEffectorMacrophagesGeneral Neurosciencevirus diseasesDendritic CellsAtherosclerosisKiller Cells Naturalmedicine.anatomical_structureCardiovascular DiseasesImmunologybiology.proteinMicrogliaCC chemokine receptorsAlzheimer’s diseaseCCR5Gene DeletionAnnals of the New York Academy of Sciences
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Intracellular coexpression of CXC- and CC– chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransp…

2014

Abstract Background Chemokines have been implicated in tumor progression and metastasis. In melanoma, chemokine receptors have been implicated in organ selective metastasis by regulating processes such as chemoattraction, adhesion and survival. Methods In this study we have analyzed, using flow cytometry, the systems formed by the chemokine receptors CXCR3, CXCR4, CXCR7, CCR7 and CCR10 and their ligands in thirteen human melanoma cell lines (five established from primary tumors and eight established from metastasis from different tissues). WM-115 and WM-266.4 melanoma cell lines (obtained from a primary and a metastatic melanoma respectively) were xenografted in nude mice and the tumors and…

Cancer ResearchChemokine receptorIntracellular SpaceBiologyCCL7LigandsChemokine receptorMiceReceptors CCRCell Line TumorGeneticsAnimalsHumansCCR10CXC chemokine receptorsCCL13MelanomaReceptors CXCRChemotaxisCell MembraneImmunohistochemistry3. Good healthCXCL2Disease Models AnimalOncologyChemokineCancer researchHeterograftsXenotransplantationCC chemokine receptorsCell lineCCL21Research ArticleBMC Cancer
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Mouse langerhans cells differentially express an activated T cell-attracting CC chemokine.

1999

Epidermal Langerhans cells represent an immature population of dendritic cells, not yet able to prime naive T cells. Following in vitro culture Langerhans cells mature into potent immunostimulatory cells. We constructed a representative cDNA library of in vitro matured murine Langerhans cells. Applying a differential screening procedure 112 differentially expressed cDNA clones were isolated. Thirty-six clones represented cDNA fragments of the same gene, identifying it to be the most actively expressed gene induced in maturing Langerhans cells. A full-length cDNA was sequenced completely. The open reading frame codes for a protein of 92 amino acids containing a leader peptide of 24 amino aci…

DNA ComplementaryT-LymphocytesMolecular Sequence DataCD1DermatologycDNA libraryBiologyLymphocyte ActivationBiochemistryCCL5MiceCXCL10Animalsdendritic cellsAmino Acid SequenceRNA MessengerchemotaxisCXCL14Molecular BiologyCXCL16Chemokine CCL22B-LymphocytesMice Inbred BALB CChemotactic FactorsCell BiologyMolecular biologyRecombinant ProteinsChemokines CCLangerhans CellsXCL2CCL25CC chemokine receptorsThe Journal of investigative dermatology
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Role of polymorphisms of CC-chemokine receptor-5 gene in acute myocardial infarction and biological implications for longevity

2008

A key component of atherosclerosis is inflammation. So, genes encoding inflammatory or antiinflammatory molecules are good candidates for the risk of cardiovascular diseases (CVD), as acute myocardial infarction (AMI). In this study we demonstrated that genetic variations in CCR5 gene affect atherosclerosis and risk of AMI, hence consenting the attainment of longevity.

MaleChemokineReceptors CCR5media_common.quotation_subjectLongevityMyocardial InfarctionInfarctionInflammationRisk FactorsmedicineHumansGenetic Predisposition to DiseaseMyocardial infarctionReceptorSicilyAllelesAgedmedia_commonAged 80 and overInflammationSettore MED/04 - Patologia Generalebiologybusiness.industryLongevityHematologyAtherosclerosismedicine.diseasePathophysiologyCardiovascular DiseasesImmunologybiology.proteinFemaleinfarction longevity CCR5medicine.symptomCC chemokine receptorsbusinessHaematologica
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Macrophage inflammatory protein-1.

2003

Macrophage inflammatory protein (MIP)-1alpha was identified 15 years ago as the first of now four members of the MIP-1 CC chemokine subfamily. These proteins termed CCL3 (MIP-1alpha), CCL4 (MIP-1beta), CCL9/10 (MIP-1delta), and CCL15 (MIP-1gamma) according to the revised nomenclature for chemokines are produced by many cells, particularly macrophages, dendritic cells, and lymphocytes. MIP-1 proteins, which act via G-protein-coupled cell surface receptors (CCR1, 3, 5), e.g. expressed by lymphocytes and monocytes/macrophages (MPhi), are best known for their chemotactic and proinflammatory effects but can also promote homoeostasis. The encouraging results of preclinical studies in murine model…

Molecular Sequence DataCCL18Cell BiologyBiologyMacrophage Inflammatory ProteinsCCL7BiochemistryCCL20CXCL2ImmunologyAnimalsHumansDiseaseCCL15Amino Acid SequenceCCL13CC chemokine receptorsChemokine CCL4Macrophage inflammatory proteinChemokine CCL3The international journal of biochemistrycell biology
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CC chemokine receptor 5Δ32 polymorphism-a risk factor for ischemic-type biliary lesions following orthotopic liver transplantation

2004

Ischemic-type biliary lesions are a major complication following orthotopic liver transplantation. They occur in up to 26% of liver transplant recipients. Among other factors, unknown immunologic factors have always been assumed to be partly responsible for these lesions. CC-chemokines and their receptors play a key role in postoperative immunomodulation after liver transplantation. The non-function CC-chemokine receptor 5Δ32 polymorphism (CCR5Δ32) has been shown to lead to a lower rate of acute rejection after kidney transplantation; in liver transplantation the role of CCR5Δ32 is unclear. We investigated the influence of the CCR5Δ32 after liver transplantation with special regard to ische…

TransplantationPathologymedicine.medical_specialtyHepatologyOrthotopic liver transplantationImmunologic Factorsbusiness.industrymedicine.medical_treatmentHeterozygote advantageLiver transplantationmedicine.diseaseGastroenterologyInternal medicinemedicineSurgeryMajor complicationReceptorbusinessCC chemokine receptorsKidney transplantationLiver Transplantation
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